Description
Cannabinoids are produced in the human body through two distinct pathways, one in vivo and one in vitro. An in vivo pathway produces the naturally occurring hexanoyl-CoA, while an in vitro pathway produces cannabinoids through the production of an olivetolic acid analog. The process involves conjugating the olivetolic acid analog with an enzyme that cleaves the molecule to create CBDV and THCV.
Cannabigerovarinic acid (CBG) is a decarboxylated form of cannabigerolic acid (CBD). CBG is found in the urine of marijuana users. It is thought to have sedative, antibacterial, and antiproliferative properties. Researchers are still investigating CBG's role in health and disease.
This phytocannabinoid has anticonvulsant effects in mice. In one study, it was shown to be effective against a mouse model of Dravet syndrome. In the other study, it was found to potentiate the anticonvulsant effect of clobazam. The anticonvulsant effects of CBGA were demonstrated when mice were subjected to a hyperthermic condition. Moreover, CBGA exhibited an inverted U-shaped dose effect, which is a common characteristic of phytocannabinoid drugs.
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