Description
Acute kidney injury (AKI), previously known as acute renal failure, represents a medical emergency and encompasses a wide range of damage to the kidneys
(AKI) occurs when kidney function rapidly deteriorates, leading to an inability to maintain fluid, electrolyte, and acid-base balance. It contributes to increased morbidity and mortality. The severity of AKI results in significant healthcare costs. Consequently, there is a heightened focus on identifying new biomarkers for AKI. Detecting AKI earlier would ultimately preserve lives, improve patients' quality of life globally, and reduce healthcare system expenses.
Due to the use of serum creatinine and urine output to fulfill diagnostic criteria, the clinical benefits of promptly and definitively diagnosing AKI have not been fully realized. These restrictions often lead to diagnostic delays, potential misclassification of actual injury status, and provide little information regarding underlying cause. Novel biomarkers of damage have shown ability to reflect ongoing kidney injury and help further refine existing Risk, Injury, Failure, Loss, End-stage kidney disease (RIFLE) and Acute Kidney Injury Network (AKIN) diagnostic criteria.
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